Ontology highlight
ABSTRACT:
SUBMITTER: Olofsen PA
PROVIDER: S-EPMC7659587 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Olofsen Patricia A PA Fatrai Szabolcs S van Strien Paulina M H PMH Obenauer Julia C JC de Looper Hans W J HWJ Hoogenboezem Remco M RM Erpelinck-Verschueren Claudia A J CAJ Vermeulen Michael P W M MPWM Roovers Onno O Haferlach Torsten T Jansen Joop H JH Ghazvini Mehrnaz M Bindels Eric M J EMJ Schneider Rebekka K RK de Pater Emma M EM Touw Ivo P IP
Cell reports. Medicine 20200825 5
Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern of leukemic transformation involves the appearance of hematopoietic clones with CSF3 receptor (<i>CSF3R</i>) mutations in the neutropenic phase, followed by mutations in <i>RUNX1</i> before AML becomes overt. To investigate how the combination of CSF3 therapy and <i>CSF3R</i> and <i>RUNX1</i> mutations contributes to AML development, we m ...[more]