Ontology highlight
ABSTRACT:
SUBMITTER: Sun G
PROVIDER: S-EPMC7659592 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Sun Guoqiang G Chiuppesi Flavia F Chen Xianwei X Wang Cheng C Tian E E Nguyen Jenny J Kha Mindy M Trinh Daniel D Zhang Hannah H Marchetto Maria C MC Song Hongjun H Ming Guo-Li GL Gage Fred H FH Diamond Don J DJ Wussow Felix F Shi Yanhong Y
Cell reports. Medicine 20200325 1
Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly understood. A major challenge for investigating HCMV-induced abnormal brain development is the strict CMV species specificity, which prevents the use of animal models to directly study brain defects caused by HCMV. We show that infection of human-induced pluripotent-stem-cell-derived brain organoids by a "clinical-like" HCMV stra ...[more]