Ontology highlight
ABSTRACT:
SUBMITTER: Clement DA
PROVIDER: S-EPMC7660225 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20201022 21
Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide phosphate (NADP) levels in many metabolic pathways. Consequently, they represent promising therapeutic targets in cancer and antibacterial treatments. We previously reported diadenosine derivatives as NAD kinase inhibitors with bactericidal activities on <i>Staphylococcus aureus</i>. Among them, one compound (namely <b>NKI1</b>) was found ...[more]