Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass.
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ABSTRACT:
SUBMITTER: Ye Y
PROVIDER: S-EPMC7660289 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass.
Ye Yuanchao Y Abu El Haija Marwa M Morgan Donald A DA Guo Deng D Song Yang Y Frank Aaron A Tian Liping L Riedl Ruth A RA Burnett Colin M L CML Gao Zhan Z Zhu Zhiyong Z Shahi Shailesh K SK Zarei Kasra K Couvelard Anne A Poté Nicolas N Ribeiro-Parenti Lara L Bado André A Noureddine Lama L Bellizzi Andrew A Kievit Paul P Mangalam Ashutosh K AK Zingman Leonid V LV Le Gall Maude M Grobe Justin L JL Kaplan Lee M LM Clegg Deborah D Rahmouni Kamal K Mokadem Mohamad M
Cell reports 20201001 4
The exact mechanisms underlying the metabolic effects of bariatric surgery remain unclear. Here, we demonstrate, using a combination of direct and indirect calorimetry, an increase in total resting metabolic rate (RMR) and specifically anaerobic RMR after Roux-en-Y gastric bypass (RYGB), but not sleeve gastrectomy (SG). We also show an RYGB-specific increase in splanchnic sympathetic nerve activity and "browning" of visceral mesenteric fat. Consequently, selective splanchnic denervation abolishe ...[more]
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