Ontology highlight
ABSTRACT:
SUBMITTER: Akef A
PROVIDER: S-EPMC7660540 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Akef Abdalla A McGraw Kathy K Cappell Steven D SD Larson Daniel R DR
PLoS biology 20201102 11
U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) forms a heterodimeric complex with U2AF2 that is primarily responsible for 3' splice site selection. U2AF1 mutations have been identified in most cancers but are prevalent in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML), and the most common mutation is a missense substitution of serine-34 to phenylalanine (S34F). The U2AF heterodimer also has a noncanonical function as a translational regulator. Here, we report that the U2AF1-S34 ...[more]