GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension.
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ABSTRACT:
SUBMITTER: Sterling JK
PROVIDER: S-EPMC7660987 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension.
Sterling Jacob K JK Adetunji Modupe O MO Guttha Samyuktha S Bargoud Albert R AR Uyhazi Katherine E KE Ross Ahmara G AG Dunaief Joshua L JL Cui Qi N QN
Cell reports 20201101 5
Glaucoma is the leading cause of irreversible blindness and is characterized by the death of retinal ganglion cells (RGCs). Recent studies have implicated pro-inflammatory microglia, macrophages, and A1 astrocytes in the pathogenesis of neurodegenerative diseases. The role of pro-inflammatory, neurotoxic A1 astrocytes in glaucoma is just beginning to be explored. Using a mouse model of glaucoma, we demonstrate that ocular hypertension is sufficient to trigger production of C1q, interleukin-1α (I ...[more]
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