Ontology highlight
ABSTRACT:
SUBMITTER: Pavlovic N
PROVIDER: S-EPMC7661042 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Pavlović Nataša N Calitz Carlemi C Thanapirom Kess K Mazza Guiseppe G Rombouts Krista K Gerwins Pär P Heindryckx Femke F
eLife 20201026
Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis. Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic micro-environment and produce growth factors and cytokines that enhance tumor cell proliferation and migration. We assessed the role of endoplasmic reticulum (ER) stress in the cross-talk between stellate cells and HCC cells. Mice with a fibrotic HCC were treated with the IRE1α-inhibitor 4μ8C, which reduced tum ...[more]