Dataset Information

Fibrosis-4 index as a predictor for mortality in hospitalised patients with COVID-19: a retrospective multicentre cohort study.

ABSTRACT:

Objective

The reliable risk factors for mortality of COVID-19 has not evaluated in well-characterised cohort. This study aimed to identify risk factors for in-hospital mortality within 56 days in patients with severe infection of COVID-19.

Design

Retrospective multicentre cohort study.

Setting

Five tertiary hospitals of Daegu, South Korea.

Participants

1005 participants over 19 years old confirmed COVID-19 using real-time PCR from nasopharyngeal and oropharyngeal swabs.

Methods

The clinical and laboratory features of patients with COVID-19 receiving respiratory support were analysed to ascertain the risk factors for mortality using the Cox proportional hazards regression model. The relationship between overall survival and risk factors was analysed using the Kaplan-Meier method.

Outcome

In-hospital mortality for any reason within 56 days.

Results

Of the 1005 patients, 289 (28.8%) received respiratory support, and of these, 70 patients (24.2%) died. In multivariate analysis, high fibrosis-4 index (FIB-4; HR 2.784), low lymphocyte count (HR 0.480), diabetes (HR 1.917) and systemic inflammatory response syndrome (HR 1.714) were found to be independent risk factors for mortality in patients with COVID-19 receiving respiratory support (all p<0.05). Regardless of respiratory support, survival in the high FIB-4 group was significantly lower than in the low FIB-4 group (28.8 days vs 44.0 days, respectively, p<0.001). A number of risk factors were also significantly related to survival in patients with COVID-19 regardless of respiratory support (0-4 risk factors, 50.2 days; 49.7 days; 44.4 days; 32.0 days; 25.0 days, respectively, p<0.001).

Conclusion

FIB-4 index is a useful predictive marker for mortality in patients with COVID-19 regardless of its severity.

SUBMITTER: Park JG

PROVIDER: S-EPMC7662142 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Fibrosis-4 index as a predictor for mortality in hospitalised patients with COVID-19: a retrospective multicentre cohort study.

Park Jung Gil JG Kang Min Kyu MK Lee Yu Rim YR Song Jeong Eun JE Kim Na Young NY Kweon Young Oh YO Tak Won Young WY Jang Se Young SY Lee Changhyeong C Kim Byung Seok BS Hwang Jae Seok JS Jang Byoung Kuk BK Bae Jinmok J Lee Ji Yeon JY Suh Jeong Ill JI Park Soo Young SY Chung Woo Jin WJ

BMJ open 20201112 11

<h4>Objective</h4>The reliable risk factors for mortality of COVID-19 has not evaluated in well-characterised cohort. This study aimed to identify risk factors for in-hospital mortality within 56 days in patients with severe infection of COVID-19.<h4>Design</h4>Retrospective multicentre cohort study.<h4>Setting</h4>Five tertiary hospitals of Daegu, South Korea.<h4>Participants</h4>1005 participants over 19 years old confirmed COVID-19 using real-time PCR from nasopharyngeal and oropharyngeal swa ...[more]

PMID: 33184086

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Dataset Information

Fibrosis-4 index as a predictor for mortality in hospitalised patients with COVID-19: a retrospective multicentre cohort study.

Objective

Design

Setting

Participants

Methods

Outcome

Results

Conclusion

Publications

Fibrosis-4 index as a predictor for mortality in hospitalised patients with COVID-19: a retrospective multicentre cohort study.

Similar Datasets

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