Functional Diversity of Non-Histone Chromosomal Protein HmgB1.

ABSTRACT: The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family-the HmgB1 protein. The proteins of the HMGB family are also known as "architectural factors" of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity

SUBMITTER: Chikhirzhina E 

PROVIDER: S-EPMC7662367 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature