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Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?

ABSTRACT: Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a progressive increase in their incidence and prevalence in the last decades. These temporal trends were observed in both pediatric and adult populations worldwide. Epidemiological and experimental studies indicate that both disorders show several common pathogenic environmental and genetic factors. In this review, we analyzed the clinical characteristics common to the two disorders and the state-of-the-art knowledge regarding the genetic predisposition and the environmental factors recognized as triggers in adult and pediatric ages. As a result of this work, we propose to consider idiopathic nephrolithiasis and osteoporosis as two possible expressions of a unique clinical syndrome. Accordingly, the clinical approach to both disorders should be modified in order to program an efficient primary and secondary prevention strategy.

SUBMITTER: Rendina D

PROVIDER: S-EPMC7662860 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?

Rendina Domenico D De Filippo Gianpaolo G Iannuzzo Gabriella G Abate Veronica V Strazzullo Pasquale P Falchetti Alberto A

International journal of molecular sciences 20201031 21

Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a progressive increase in their incidence and prevalence in the last decades. These temporal trends were observed in both pediatric and adult populations worldwide. Epidemiological and experimental studies indicate that both disorders show several common pathogenic environmental and genetic factors. In this review, we analyzed the clinical characteristics common to the two disorders and the state-of-the-art knowle ...[more]

PMID: 33142950

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