In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion.
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ABSTRACT:
SUBMITTER: Giraud S
PROVIDER: S-EPMC7662866 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion.
Giraud Sebastien S Thuillier Raphaël R Cau Jérome J Hauet Thierry T
International journal of molecular sciences 20201031 21
Oxidative stress is a key element of ischemia-reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear improvement of preservation quality, particularly for marginal donors, such as extended criteria donors (ECDs) and donation after circulatory death (DCDs). Nevertheless, complications still exist, fosteri ...[more]
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