Ontology highlight
ABSTRACT:
SUBMITTER: Schroder M
PROVIDER: S-EPMC7663056 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Schröder Martin M Filippakopoulos Panagis P Schwalm Martin P MP Ferrer Carla A CA Drewry David H DH Knapp Stefan S Chaikuad Apirat A
International journal of molecular sciences 20201026 21
Extracellular signal-regulated kinase 3 (ERK3), known also as mitogen-activated protein kinase 6 (MAPK6), is an atypical member of MAPK kinase family, which has been poorly studied. Little is known regarding its function in biological processes, yet this atypical kinase has been suggested to play important roles in the migration and invasiveness of certain cancers. The lack of tools, such as a selective inhibitor, hampers the study of ERK3 biology. Here, we report the crystal structure of the ki ...[more]