KV11.1, NaV1.5, and CaV1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity.
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ABSTRACT:
SUBMITTER: Kowalska M
PROVIDER: S-EPMC7663169 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity.
Kowalska Magdalena M Nowaczyk Jacek J Nowaczyk Alicja A
International journal of molecular sciences 20201030 21
Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart's work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and ...[more]
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