Ontology highlight
ABSTRACT:
SUBMITTER: Trevis KJ
PROVIDER: S-EPMC7663259 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Trevis Krysta J KJ Brown Natasha J NJ Green Cherie C CC Lockhart Paul J PJ Desai Tarishi T Vick Tanya T Anderson Vicki V Pua Emmanuel P K EPK Bahlo Melanie M Delatycki Martin B MB Scheffer Ingrid E IE Wilson Sarah J SJ
International journal of molecular sciences 20201027 21
Families comprising many individuals with Autism Spectrum Disorders (ASD) may carry a dominant predisposing mutation. We implemented rigorous phenotyping of the "Broader Autism Phenotype" (BAP) in large multiplex ASD families using a novel endophenotype approach for the identification and characterisation of distinct BAP endophenotypes. We evaluated ASD/BAP features using standardised tests and a semi-structured interview to assess social, intellectual, executive and adaptive functioning in 110 ...[more]