Targeting the JAK2/STAT3 Pathway-Can We Compare It to the Two Faces of the God Janus?
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ABSTRACT:
SUBMITTER: Jaskiewicz A
PROVIDER: S-EPMC7663396 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Targeting the JAK2/STAT3 Pathway-Can We Compare It to the Two Faces of the God Janus?
Jaśkiewicz Anna A Domoradzki Tomasz T Pająk Beata B
International journal of molecular sciences 20201104 21
Muscle cachexia is one of the most critical unmet medical needs. Identifying the molecular background of cancer-induced muscle loss revealed a promising possibility of new therapeutic targets and new drug development. In this review, we will define the signal transducer and activator of transcription 3 (STAT3) protein's role in the tumor formation process and summarize the role of STAT3 in skeletal muscle cachexia. Finally, we will discuss a vast therapeutic potential for the STAT3-inhibiting si ...[more]
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