Ontology highlight
ABSTRACT:
SUBMITTER: Ton AT
PROVIDER: S-EPMC7663809 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Ton Anh-Tien AT Singh Kriti K Morin Hélène H Ban Fuqiang F Leblanc Eric E Lee Joseph J Lallous Nada N Cherkasov Artem A
International journal of molecular sciences 20201105 21
Resistance to androgen-receptor (AR) directed therapies is, among other factors, associated with Myc transcription factors that are involved in development and progression of many cancers. Overexpression of N-Myc protein in prostate cancer (PCa) leads to its transformation to advanced neuroendocrine prostate cancer (NEPC) that currently has no approved treatments. N-Myc has a short half-life but acts as an NEPC stimulator when it is stabilized by forming a protective complex with Aurora A kinase ...[more]