Ontology highlight
ABSTRACT:
SUBMITTER: Cohen MA
PROVIDER: S-EPMC7663823 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Cohen Malkiel A MA Zhang Shupei S Sengupta Satyaki S Ma Haiting H Bell George W GW Horton Brendan B Sharma Bandana B George Rani E RE Spranger Stefani S Jaenisch Rudolf R
Cell stem cell 20200305 4
Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracranial solid tumor. Here, we establish a platform that allows the study of human NBs in mouse-human NC chimeras. Chimeric mice were produced by injecting human NC cells carrying NB relevant oncogenes in utero into gastrulating mouse embryos. The mice developed tumors composed of a heterogenous cell population that resembled that seen in primary NBs of patients but were significantly different from homogene ...[more]