Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection.
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ABSTRACT:
SUBMITTER: Turjya RR
PROVIDER: S-EPMC7664154 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection.
Turjya Rafeed Rahman RR Khan Md Abdullah-Al-Kamran MA Mir Md Khademul Islam Abul Bashar AB
Future virology 20200901 9
<h4>Background</h4>Regulatory roles of long noncoding RNAs (lncRNAs) during viral infection has become more evident in last decade, but are yet to be explored for SARS-CoV-2.<h4>Materials & methods</h4>We analyzed RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells to identify differentially expressed genes.<h4>Results</h4>Our analyses uncover 21 differentially expressed lncRNAs broadly involved in cell survival and regulation of gene expression. These lncRNAs can directly interact with ...[more]
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