Ontology highlight
ABSTRACT:
SUBMITTER: Choi W
PROVIDER: S-EPMC7664156 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Choi Woosuk W Choe Shawn S Lin Jingjun J Borchers Michael T MT Kosmider Beata B Vassallo Robert R Limper Andrew H AH Lau Gee W GW
Mucosal immunology 20200207 4
Goblet cell hyperplasia and metaplasia and excessive mucus are prominent pathologies of chronic airway diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and chronic bronchitis. Chronic infection by respiratory pathogens, including Pseudomonas aeruginosa, exacerbates cyclical proinflammatory responses and mucus hypersecretion. P. aeruginosa and its virulence factor pyocyanin contribute to these pathologies by inhibiting FOXA2, a key transcriptional regulator of ...[more]