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Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.


ABSTRACT: As microbial therapeutics are increasingly being tested in diverse patient populations, it is essential to understand the host and environmental factors influencing the microbiome. Through analysis of 1,359 gut microbiome samples from 946 healthy donors of the Milieu Intérieur cohort, we detail how microbiome composition is associated with host factors, lifestyle parameters, and disease states. Using a genome-based taxonomy, we found biological sex was the strongest driver of community composition. Additionally, bacterial populations shift across decades of life (age 20-69), with Bacteroidota species consistently increased with age while Actinobacteriota species, including Bifidobacterium, decreased. Longitudinal sampling revealed that short-term stability exceeds interindividual differences. By accounting for these factors, we defined global shifts in the microbiomes of patients with non-gastrointestinal tumors compared with healthy donors. Together, these results demonstrated that the microbiome displays predictable variations as a function of sex, age, and disease state. These variations must be considered when designing microbiome-targeted therapies or interpreting differences thought to be linked to pathophysiology or therapeutic response.

SUBMITTER: Byrd AL 

PROVIDER: S-EPMC7664509 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.

Byrd Allyson L AL   Liu Menghan M   Fujimura Kei E KE   Lyalina Svetlana S   Nagarkar Deepti R DR   Charbit Bruno B   Bergstedt Jacob J   Patin Etienne E   Harrison Oliver J OJ   Quintana-Murci Lluís L   Mellman Ira I   Duffy Darragh D   Albert Matthew L ML  

The Journal of experimental medicine 20210101 1


As microbial therapeutics are increasingly being tested in diverse patient populations, it is essential to understand the host and environmental factors influencing the microbiome. Through analysis of 1,359 gut microbiome samples from 946 healthy donors of the Milieu Intérieur cohort, we detail how microbiome composition is associated with host factors, lifestyle parameters, and disease states. Using a genome-based taxonomy, we found biological sex was the strongest driver of community compositi  ...[more]

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