Ontology highlight
ABSTRACT:
SUBMITTER: Lu SL
PROVIDER: S-EPMC7664670 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Lu Shao-Lun SL Liu Wei-Wen WW Cheng Jason Chia-Hsien JC Lin Lien-Chieh LC Wang Churng-Ren Chris CC Li Pai-Chi PC
International journal of molecular sciences 20201108 21
We demonstrate the megavoltage (MV) radiosensitization of a human liver cancer line by combining gold-nanoparticle-encapsulated microbubbles (AuMBs) with ultrasound. Microbubbles-mediated sonoporation was administered for 5 min, at 2 h prior to applying radiotherapy. The intracellular concentration of gold nanoparticles (AuNPs) increased with the inertial cavitation of AuMBs in a dose-dependent manner. A higher inertial cavitation dose was also associated with more DNA damage, higher levels of a ...[more]