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Enhanced Radiosensitization for Cancer Treatment with Gold Nanoparticles through Sonoporation.


ABSTRACT: We demonstrate the megavoltage (MV) radiosensitization of a human liver cancer line by combining gold-nanoparticle-encapsulated microbubbles (AuMBs) with ultrasound. Microbubbles-mediated sonoporation was administered for 5 min, at 2 h prior to applying radiotherapy. The intracellular concentration of gold nanoparticles (AuNPs) increased with the inertial cavitation of AuMBs in a dose-dependent manner. A higher inertial cavitation dose was also associated with more DNA damage, higher levels of apoptosis markers, and inferior cell surviving fractions after MV X-ray irradiation. The dose-modifying ratio in a clonogenic assay was 1.56 ± 0.45 for a 10% surviving fraction. In a xenograft mouse model, combining vascular endothelial growth factor receptor 2 (VEGFR2)-targeted AuMBs with sonoporation significantly delayed tumor regrowth. A strategy involving the spatially and temporally controlled release of AuNPs followed by clinically utilized MV irradiation shows promising results that make it worthy of further translational investigations.

SUBMITTER: Lu SL 

PROVIDER: S-EPMC7664670 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Enhanced Radiosensitization for Cancer Treatment with Gold Nanoparticles through Sonoporation.

Lu Shao-Lun SL   Liu Wei-Wen WW   Cheng Jason Chia-Hsien JC   Lin Lien-Chieh LC   Wang Churng-Ren Chris CC   Li Pai-Chi PC  

International journal of molecular sciences 20201108 21


We demonstrate the megavoltage (MV) radiosensitization of a human liver cancer line by combining gold-nanoparticle-encapsulated microbubbles (AuMBs) with ultrasound. Microbubbles-mediated sonoporation was administered for 5 min, at 2 h prior to applying radiotherapy. The intracellular concentration of gold nanoparticles (AuNPs) increased with the inertial cavitation of AuMBs in a dose-dependent manner. A higher inertial cavitation dose was also associated with more DNA damage, higher levels of a  ...[more]

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