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Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension.


ABSTRACT:

Objective

To quantify and compare levels of potential biomarkers in neonates with (i) Bronchopulmonary dysplasia (BPD); (ii) BPD-associated pulmonary hypertension (BPD-PH); (iii) PH without BPD; and (iv) neonates without lung disease at ~36 weeks postmenstrual age.

Study design

Multiple potential biomarkers were measured in plasma samples of 90 patients using a multi-spot enzyme-linked immunosorbent assay. Statistical tests done included one-way ANOVA to compare levels of biomarkers between different groups.

Results

Higher levels of ICAM-1 were present in infants with BPD and correlated with its severity. Infants with BPD have significantly higher levels of ANG-2 and lower levels of ANG-1. Infants with PH have higher levels of: IL-6, IL-8, IL-10, and TNF-?. Infants with BPD-PH have significantly lower levels of MCP-1 and higher levels of IL-1? than infants with PH without BPD.

Conclusion

ICAM-1 may be used as a specific biomarker for diagnosis of BPD and its severity.

SUBMITTER: Sahni M 

PROVIDER: S-EPMC7664991 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension.

Sahni Mitali M   Yeboah Bettie B   Das Pragnya P   Shah Dilip D   Ponnalagu Devasena D   Singh Harpreet H   Nelin Leif D LD   Bhandari Vineet V  

Journal of perinatology : official journal of the California Perinatal Association 20200818 11


<h4>Objective</h4>To quantify and compare levels of potential biomarkers in neonates with (i) Bronchopulmonary dysplasia (BPD); (ii) BPD-associated pulmonary hypertension (BPD-PH); (iii) PH without BPD; and (iv) neonates without lung disease at ~36 weeks postmenstrual age.<h4>Study design</h4>Multiple potential biomarkers were measured in plasma samples of 90 patients using a multi-spot enzyme-linked immunosorbent assay. Statistical tests done included one-way ANOVA to compare levels of biomarke  ...[more]

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