Ontology highlight
ABSTRACT:
SUBMITTER: Philyppov IB
PROVIDER: S-EPMC7665011 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Philyppov Igor B IB Sotkis Ganna V GV Rock Aurelien A Roudbaraki Morad M Bonnal Jean-Louis JL Mauroy Brigitte B Prevarskaya Natalia N Shuba Yaroslav M YM
Scientific reports 20201112 1
Urinary incontinence of idiopathic nature is a common complication of bladder cancer, yet, the mechanisms underlying changes in bladder contractility associated with cancer are not known. Here by using tensiometry on detrusor smooth muscle (DSM) strips from normal rats and rats with bladder cancer induced by known urothelial carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), we show that bladder cancer is associated with considerable changes in DSM contractility. These changes include: (1) ...[more]