Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.
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ABSTRACT:
SUBMITTER: Neumann A
PROVIDER: S-EPMC7665047 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.
Neumann Alexander A Walton Esther E Alemany Silvia S Cecil Charlotte C González Juan Ramon JR Jima Dereje D DD Lahti Jari J Tuominen Samuli T ST Barker Edward D ED Binder Elisabeth E Caramaschi Doretta D Carracedo Ángel Á Czamara Darina D Evandt Jorunn J Felix Janine F JF Fuemmeler Bernard F BF Gutzkow Kristine B KB Hoyo Cathrine C Julvez Jordi J Kajantie Eero E Laivuori Hannele H Maguire Rachel R Maitre Léa L Murphy Susan K SK Murcia Mario M Villa Pia M PM Sharp Gemma G Sunyer Jordi J Raikkönen Katri K Bakermans-Kranenburg Marian M IJzendoorn Marinus van MV Guxens Mònica M Relton Caroline L CL Tiemeier Henning H
Translational psychiatry 20201112 1
Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is unknown. We performed epigenome-wide association studies (EWAS) within the Pregnancy And Childhood Epigenetics (PACE) Consortium to identify DNA methylation sites associated with ADHD symptoms at two methylation assessment periods: birth and school age. We examined associations of ...[more]
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