Ontology highlight
ABSTRACT:
SUBMITTER: Radlinger B
PROVIDER: S-EPMC7665199 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Radlinger Bernhard B Hornsteiner Florian F Folie Sabrina S Salvenmoser Willi W Haubner Bernhard J BJ Schuetz Thomas T Haas Simone S Ress Claudia C Adolph Timon E TE Salzmann Karin K Weiss Bernhard B Tilg Herbert H Kaser Susanne S
Scientific reports 20201112 1
Sodium glucose transporter (SGLT)-2 inhibitors have consistently shown cardioprotective effects independent of the glycemic status of treated patients. In this study we aimed to investigate underlying mechanisms of short-term empagliflozin treatment in a mouse model of type II diabetes. Male db/db mice were fed a western type diet with or without enrichment with empagliflozin for 7 days. While glucose tolerance was significantly improved in empagliflozin treated mice, body weight and fasting ins ...[more]