Ontology highlight
ABSTRACT:
SUBMITTER: Scarpa E
PROVIDER: S-EPMC7665645 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Scarpa Edoardo E De Pace Cesare C Joseph Adrian Steve AS de Souza Senio Campos SC Poma Alessandro A Liatsi-Douvitsa Eva E Contini Claudia C De Matteis Valeria V Martí Josep Samitier JS Battaglia Giuseppe G Rizzello Loris L
PloS one 20201113 11
We investigated how the shape of polymeric vesicles, made by the exact same material, impacts the replication activity and metabolic state of both cancer and non-cancer cell types. First, we isolated discrete geometrical structures (spheres and tubes) from a heterogeneous sample using density-gradient centrifugation. Then, we characterized the cellular internalization and the kinetics of uptake of both types of polymersomes in different cell types (either cancer or non-cancer cells). We also inv ...[more]