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Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study.


ABSTRACT: Depression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N?=?268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS-D) at four time points (baseline, and after 1 month, 6 months, and 12 months). The functional FKBP5 single-nucleotide polymorphism (SNP) rs1360780 was selected for genotyping. Linear regression models showed that a higher number of FKBP5 C alleles was associated with more depressive symptoms in CHD patients both at baseline (p?=?0.015) and at 12-months follow-up (p?=?0.025) after adjustment for confounders. Further analyses revealed that this effect was driven by an interaction of FKBP5 genotype with patients' prior CHD course. Specifically, only in patients with a prior myocardial infarction or coronary revascularization, more depressive symptoms were associated with a higher number of C alleles (baseline: p?=?0.046; 1-month: p?=?0.026; 6-months: p?=?0.028). Moreover, a higher number of C alleles was significantly related to a greater risk for dyslipidemia (p?=?.016). Our results point to a relevance of FKBP5 in the association of the two stress-related diseases depression and CHD.

SUBMITTER: Brandt J 

PROVIDER: S-EPMC7665971 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study.

Brandt Julia J   Warnke Katharina K   Jörgens Silke S   Arolt Volker V   Beer Katja K   Domschke Katharina K   Haverkamp Wilhelm W   Kuhlmann Stella L SL   Müller-Nordhorn Jacqueline J   Rieckmann Nina N   Schwarte Kathrin K   Ströhle Andreas A   Tschorn Mira M   Waltenberger Johannes J   Grosse Laura L  

Journal of neural transmission (Vienna, Austria : 1996) 20200829 12


Depression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N = 268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Dep  ...[more]

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