Exosome markers of LRRK2 kinase inhibition.
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ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC7666125 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Exosome markers of LRRK2 kinase inhibition.
Wang Shijie S Kelly Kaela K Brotchie Jonathan M JM Koprich James B JB West Andrew B AB
NPJ Parkinson's disease 20201113 1
Hyper-activated LRRK2 is linked to Parkinson's disease susceptibility and progression. Quantitative measures of LRRK2 inhibition, especially in the brain, maybe critical in the development of successful LRRK2-targeting therapeutics. In this study, two different brain-penetrant and selective LRRK2 small-molecule kinase inhibitors (PFE-360 and MLi2) were orally administered to groups of cynomolgus macaques. Proposed pharmacodynamic markers in exosomes from urine and cerebrospinal fluid (CSF) were ...[more]
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