Ontology highlight
ABSTRACT:
SUBMITTER: Lou J
PROVIDER: S-EPMC7666136 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Lou Jieqiong J Priest David G DG Solano Ashleigh A Kerjouan Adèle A Hinde Elizabeth E
Nature communications 20201113 1
Tumor suppressor p53-binding protein 1 (53BP1) is a DNA repair protein essential for the detection, assessment, and resolution of DNA double strand breaks (DSBs). The presence of a DSB is signaled to 53BP1 via a local histone modification cascade that triggers the binding of 53BP1 dimers to chromatin flanking this type of lesion. While biochemical studies have established that 53BP1 exists as a dimer, it has never been shown in a living cell when or where 53BP1 dimerizes upon recruitment to a DS ...[more]