Ontology highlight
ABSTRACT:
SUBMITTER: Wickham SFJ
PROVIDER: S-EPMC7666213 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Wickham Shelley F J SFJ Auer Alexander A Min Jianghong J Ponnuswamy Nandhini N Woehrstein Johannes B JB Schueder Florian F Strauss Maximilian T MT Schnitzbauer Jörg J Nathwani Bhavik B Zhao Zhao Z Perrault Steven D SD Hahn Jaeseung J Lee Seungwoo S Bastings Maartje M MM Helmig Sarah W SW Kodal Anne Louise AL Yin Peng P Jungmann Ralf R Shih William M WM
Nature communications 20201113 1
DNA origami, in which a long scaffold strand is assembled with a many short staple strands into parallel arrays of double helices, has proven a powerful method for custom nanofabrication. However, currently the design and optimization of custom 3D DNA-origami shapes is a barrier to rapid application to new areas. Here we introduce a modular barrel architecture, and demonstrate hierarchical assembly of a 100 megadalton DNA-origami barrel of ~90 nm diameter and ~250 nm height, that provides a rhom ...[more]