Ontology highlight
ABSTRACT:
SUBMITTER: Cuneo A
PROVIDER: S-EPMC7666748 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cuneo Antonio A Mato Anthony R AR Rigolin Gian Matteo GM Piciocchi Alfonso A Gentile Massimo M Laurenti Luca L Allan John N JN Pagel John M JM Brander Danielle M DM Hill Brian T BT Winter Allison A Lamanna Nicole N Tam Constantine S CS Jacobs Ryan R Lansigan Frederick F Barr Paul M PM Shadman Mazyar M Skarbnik Alan P AP Pu Jeffrey J JJ Sehgal Alison R AR Schuster Stephen J SJ Shah Nirav N NN Ujjani Chaitra S CS Roeker Lindsey L Orlandi Ester Maria EM Billio Atto A Trentin Livio L Spacek Martin M Marchetti Monia M Tedeschi Alessandra A Ilariucci Fiorella F Gaidano Gianluca G Doubek Michael M Farina Lucia L Molica Stefano S Di Raimondo Francesco F Coscia Marta M Mauro Francesca Romana FR de la Serna Javier J Medina Perez Angeles A Ferrarini Isacco I Cimino Giuseppe G Cavallari Maurizio M Cucci Rosalba R Vignetti Marco M Foà Robin R Ghia Paolo P
Cancer medicine 20200924 22
Limited information is available on the efficacy of front-line bendamustine and rituximab (BR) in chronic lymphocytic leukemia (CLL) with reduced renal function or coexisting conditions. We therefore analyzed a cohort of real-world patients and performed a matched adjusted indirect comparison with a cohort of patients treated with ibrutinib. One hundred and fifty-seven patients with creatinine clearance (CrCl) <70 mL/min and/or CIRS score >6 were treated with BR. The median age was 72 years; 69% ...[more]