Dataset Information

Variability in body weight precedes diagnosis in dementia: A nationwide cohort study.

ABSTRACT:

Background

While there have been disagreements concerning whether obesity and increase in body weight elevate the risk of dementia, variability in body weight has been recently recognized as a new biometric associated with a high risk for a number of diseases. This nationwide, population-based cohort study examined the association between body weight variability and dementia.

Methods

A total of 2,812,245 adults (mean age, 51.7 years; standard deviation, 8.6) without a history of dementia who underwent at least three health examinations between 2005 and 2012 in a nationwide cohort were followed-up until the date of dementia diagnosis (based on prescribed drugs and disease code) or until 2016 (median follow-up duration, 5.38 years; interquartile range, 5.16-5.61). Cox regression models were used to evaluate the risk of Alzheimer's disease and vascular dementia according to body weight variability.

Results

The hazard ratios (95% confidence intervals) of the highest quartiles of variability were 1.42 (1.35-1.49) for Alzheimer's disease and 1.47 (1.32-1.63) for vascular dementia compared to the lowest quartile group as a reference. This association was consistent in various subgroup analyses and sensitivity analyses.

Conclusions

Body weight variability could predict Alzheimer's disease and vascular dementia, which may provide new insights into the prevention and management of dementia.

SUBMITTER: Ha J

PROVIDER: S-EPMC7667348 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Variability in body weight precedes diagnosis in dementia: A nationwide cohort study.

Ha Jane J Kwon Yeongkeun Y Kwon Ye-Ji YJ Kim DaHye D Han Kyungdo K Jang Mi M Park Sungsoo S Nam Ga Eun GE Kim Yang Hyun YH Kim Do Hoon DH Park Yong Gyu YG Cho Kyung-Hwan KH

Brain and behavior 20200828 11

<h4>Background</h4>While there have been disagreements concerning whether obesity and increase in body weight elevate the risk of dementia, variability in body weight has been recently recognized as a new biometric associated with a high risk for a number of diseases. This nationwide, population-based cohort study examined the association between body weight variability and dementia.<h4>Methods</h4>A total of 2,812,245 adults (mean age, 51.7 years; standard deviation, 8.6) without a history of d ...[more]

PMID: 32856784

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Dataset Information

Variability in body weight precedes diagnosis in dementia: A nationwide cohort study.

Background

Methods

Results

Conclusions

Publications

Variability in body weight precedes diagnosis in dementia: A nationwide cohort study.

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