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Altered long- and short-range functional connectivity density associated with poor sleep quality in patients with chronic insomnia disorder: A resting-state fMRI study.

ABSTRACT: INTRODUCTION:Previous neuroimaging studies have suggested that brain functional impairment and hyperarousal occur during the daytime among patients with chronic insomnia disorder (CID); however, alterations to the brain's intrinsic functional architecture and their association with sleep quality have not yet been documented. METHODS:In this study, our aim was to investigate the insomnia-related alterations to the intrinsic connectome in patients with CID (n = 27) at resting state, with a data-driven approach based on graph theory assessment and functional connectivity density (FCD), which can be interpreted as short-range (intraregional) or long-range (interregional) mapping. RESULTS:Compared with healthy controls with good sleep, CID patients showed significantly decreased long-range FCD in the dorsolateral prefrontal cortices and the putamen. These patients also showed decreased short-range FCD in their multimodal-processing regions, executive control network, and supplementary motor-related areas. Furthermore, several regions showed increased short-range FCD in patients with CID, implying hyper-homogeneity of local activity. CONCLUSIONS:Together, these findings suggest that insufficient sleep during chronic insomnia widely affects cortical functional activities, including disrupted FCD and increased short-range FCD, which is associated with poor sleep quality.

SUBMITTER: Zhou F

PROVIDER: S-EPMC7667361 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Altered long- and short-range functional connectivity density associated with poor sleep quality in patients with chronic insomnia disorder: A resting-state fMRI study.

Zhou Fuqing F Zhu Yanyan Y Zhu Yujun Y Huang Muhua M Jiang Jian J He Laichang L Huang Suhua S Zeng Xianjun X Gong Honghan H

Brain and behavior 20200916 11

<h4>Introduction</h4>Previous neuroimaging studies have suggested that brain functional impairment and hyperarousal occur during the daytime among patients with chronic insomnia disorder (CID); however, alterations to the brain's intrinsic functional architecture and their association with sleep quality have not yet been documented.<h4>Methods</h4>In this study, our aim was to investigate the insomnia-related alterations to the intrinsic connectome in patients with CID (n = 27) at resting state, ...[more]

PMID: 32935924

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Project description:BackgroundMillions of COVID-19 survivors experience a wide range of long-term symptoms after acute infection, giving rise to serious public health concerns. To date, few risk factors for post-COVID-19 conditions have been determined. This study evaluated the role of pre-infection sleep quality/duration and insomnia severity in the incidence of long-term symptoms after COVID-19.Material and methodsThis prospective study involved two assessments (April 2020 and 2022). At the baseline (April 2020), sleep quality/duration and insomnia symptoms in participants without current/prior SARS-CoV-2 infection were measured using the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI). At the follow-up (April 2022), we asked a group of COVID-19 survivors to retrospectively evaluate the presence of twenty-one symptoms (psychiatric, neurological, cognitive, bodily, and respiratory) that have been experienced one month (n = 713, infection in April 2020-February 2022) and three months after COVID-19 (n = 333, infection in April 2020-December 2021). In April 2022, participants also reported how many weeks passed to fully recover from COVID-19. Zero-inflated negative binomial models were used to estimate the effect of previous sleep on the number of long-term symptoms. Binomial logistic regressions were performed to evaluate the association between sleep variables, the incidence of each post-COVID-19 symptom, and the odds of recovery four/twelve weeks after infection.ResultsAnalyses highlighted a significant effect of pre-infection sleep on the number of symptoms one/three months after COVID-19. Previous higher PSQI and ISI scores, and shorter sleep duration significantly increased the risk of almost every long-term symptom at one/three months from COVID-19. Baseline sleep problems were also associated with longer recovery times to return to the pre-infection daily functioning level after COVID-19.ConclusionsThis study suggested a prospective dose-dependent association between pre-infection sleep quality/quantity and insomnia severity with the manifestation of post-COVID-19 symptoms. Further research is warranted to determine whether preventively promoting sleep health may mitigate the COVID-19 sequelae, with substantial public health and societal implications.

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Altered long- and short-range functional connectivity density associated with poor sleep quality in patients with chronic insomnia disorder: A resting-state fMRI study.

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Altered long- and short-range functional connectivity density associated with poor sleep quality in patients with chronic insomnia disorder: A resting-state fMRI study.

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