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In-vitro Studies of Anti-EGFR Tyrosine Kinase Activity of Thai nutraceutical Plants.

ABSTRACT: Functional foods have emerged as a new approach to improve human health in term of nutraceutical to prevent people from illness rather than cure patients through medical treatment. In Asian society, particularly in Thailand, the utilizations of functional ingredients have been integrated in every parts of ordinary life. In this study, the tyrosine kinase activity of epidermal growth factor receptor (EGFR) inhibiting properties of 23 Thai's herbs-ethanol extracts have been examined. The crude extracts of only four species that inhibit the activity of EGFR-tyrosine kinase, Azadirachta indica (neem, Sa-dao), Brucea javanica (L.) Merr. (Rajadad), Hibiscus sabdariffa L. (Roselle, Krachiap daeng), and Saccharum chinensis Roxb. (Red sugar cane). Moreover, only ethanol extractions from A. indica and B. javanica were also showed antitumor effect to non-small cell lung cancer, A549 cells.

SUBMITTER: Semsri S 

PROVIDER: S-EPMC7667552 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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<i>In-vitro</i> Studies of Anti-EGFR Tyrosine Kinase Activity of Thai nutraceutical Plants.

Semsri Suwanna S   Seatew Chanyatorn C   Rattanabunyong Siriluk S   Ruekit Sirigade S   Horata Natharinee N   Panya Aussara A   Yenchitsomanus Pa-Thai PT   Sawatdichaikul Orathai O   Choowongkomon Kiattawee K  

Iranian journal of pharmaceutical research : IJPR 20200101 2

Functional foods have emerged as a new approach to improve human health in term of nutraceutical to prevent people from illness rather than cure patients through medical treatment. In Asian society, particularly in Thailand, the utilizations of functional ingredients have been integrated in every parts of ordinary life. In this study, the tyrosine kinase activity of epidermal growth factor receptor (EGFR) inhibiting properties of 23 Thai's herbs-ethanol extracts have been examined. The crude ext  ...[more]

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