Ontology highlight
ABSTRACT:
SUBMITTER: Wander DPA
PROVIDER: S-EPMC7667640 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Wander Dennis P A DPA van der Zanden Sabina Y SY van der Marel Gijsbert A GA Overkleeft Herman S HS Neefjes Jacques J Codée Jeroen D C JDC
Journal of medicinal chemistry 20201016 21
Anthracycline anticancer drugs doxorubicin and aclarubicin have been used in the clinic for several decades to treat various cancers. Although closely related structures, their molecular mode of action diverges, which is reflected in their biological activity profile. For a better understanding of the structure-function relationship of these drugs, we synthesized ten doxorubicin/aclarubicin hybrids varying in three distinct features: aglycon, glycan, and amine substitution pattern. We continued ...[more]