Ontology highlight
ABSTRACT:
SUBMITTER: Konishi H
PROVIDER: S-EPMC7667883 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20200922 22
Microglia are the principal phagocytes that clear cell debris in the central nervous system (CNS). This raises the question, which cells remove cell debris when microglial phagocytic activity is impaired. We addressed this question using Siglech<sup>dtr</sup> mice, which enable highly specific ablation of microglia. Non-microglial mononuclear phagocytes, such as CNS-associated macrophages and circulating inflammatory monocytes, did not clear microglial debris. Instead, astrocytes were activated, ...[more]