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Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer.

ABSTRACT: Background/Aims:Multiple meta-analyses and observational studies have reported that alcohol is a risk factor for liver cancer. However, whether there is a safe level of alcohol consumption remains unclear. We performed a systematic review and meta-analysis of the correlation between low-level alcohol consumption and the risk of liver cancer. Methods:Nested case-control studies and cohort studies involving the general population published prior to July 2019 were searched. In total, 28 publications (31 cohorts) with 4,899 incident cases and 10,859 liver cancer-related deaths were included. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results:Compared with those with low levels of alcohol consumption, moderate and heavy drinkers (?1 drink/day for females and ?2 drinks/day for males) had pooled ORs of 1.418 (95% CI, 1.192 to 1.687; p<0.001) for liver cancer incidence and 1.167 (95% CI, 1.056 to 1.290; p=0.003) for liver cancer mortality. The pooled OR for liver disease-related mortality for those with more than low levels of alcohol consumption was 3.220 (95% CI, 2.116 to 4.898; p<0.001) and that for all-cause mortality was 1.166 (95% CI, 1.065 to 1.278; p=0.001). The sensitivity analysis showed that none of the studies had a strong effect on the pooled OR. The Egger test, Begg rank correlation test, and the funnel plot showed no overt indication of publication bias. Conclusions:Continuous consumption of more than a low-level of alcohol (?1 drink/day for females and ?2 drinks/ day for males) is related to a higher risk of liver cancer.

SUBMITTER: Park H

PROVIDER: S-EPMC7667924 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer.

Park Hana H Shin Seung Kak SK Joo Ijin I Song Do Seon DS Jang Jeong Won JW Park Joong-Won JW

Gut and liver 20201101 6

<h4>Background/aims</h4>Multiple meta-analyses and observational studies have reported that alcohol is a risk factor for liver cancer. However, whether there is a safe level of alcohol consumption remains unclear. We performed a systematic review and meta-analysis of the correlation between low-level alcohol consumption and the risk of liver cancer.<h4>Methods</h4>Nested case-control studies and cohort studies involving the general population published prior to July 2019 were searched. In total, ...[more]

PMID: 32135583

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Project description:BackgroundThe published data about alcohol consumption and uterine myoma are scanty and controversial: some studies found positive association whereas other studies showed no association.ObjectivesTo conduct a systematic review and meta-analysis to determine whether alcohol is a risk factor for myoma.Search strategyA MEDLINE/EMBASE search was carried out, supplemented by manual searches of bibliographies of the selected studies.Selection criteriaArticles published as full-length papers in English. In the review we included all identified studies. Otherwise, the inclusion criteria for studies included in the meta-analysis were: a) case-control or cohort studies, reporting original data; b) studies reporting original data on the association between alcohol consumption and myoma; c) diagnosis of myoma was ultrasound or histological confirmed and/or clinically based.Data collection and analysisA total of 6 studies were identified for the review and 5 studies were included in the meta-analysis. The primary outcome was the incidence of uterine myoma in ever versus never alcohol drinkers and when data were available, we also analyzed categories of alcohol intake. We assessed the outcomes in the overall population and then we performed a subgroup analysis according to study design. Pooled estimates of the odds ratios (OR) with 95% confidence interval (CI) were calculated using random effects models.Main resultsThe summary OR (95%CI) of myoma forever versus never alcohol intake was 1.12 (0.94-1.34) with significant heterogeneity. The summary OR for current versus never drinking was 1.33 (1.01-1.76) with no heterogeneity.ConclusionsEver alcohol consumption is not associated with myoma risk. Based on the data of two studies, current alcohol drinkers had a slightly borderline increased risk of diagnosis of myoma. In consideration of the very limited number of studies and the suggestion of a potential increased risk among current drinkers, further studies are required.

Dataset Information

Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer.

Publications

Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer.

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