Ontology highlight
ABSTRACT:
SUBMITTER: Le CT
PROVIDER: S-EPMC7668254 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Le Cong Truc CT Nguyen Thuy Linh TL Nguyen Trung Duc TD Nguyen Tuan Anh TA
RNA (New York, N.Y.) 20200929 12
The Microprocessor complex of DROSHA and DGCR8 initiates the biosynthesis of microRNAs (miRNAs) by processing primary miRNAs (pri-miRNAs). The Microprocessor can be oriented on pri-miRNAs in opposite directions to generate productive and unproductive cleavages at their basal and apical junctions, respectively. However, only the productive cleavage gives rise to miRNAs. A single nucleotide polymorphism (SNP, rs2910164) in pri-mir-146a is associated with various human diseases. Although this SNP w ...[more]