Ontology highlight
ABSTRACT:
SUBMITTER: Jin C
PROVIDER: S-EPMC7668386 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Jin Celina C Hill Jennifer J Gunn Bronwyn M BM Yu Wen-Han WH Dahora Lindsay C LC Jones Elizabeth E Johnson Mari M Gibani Malick M MM Spreng Rachel L RL Alam S Munir SM Nebykova Anna A Juel Helene B HB Dennison S Moses SM Seaton Kelly E KE Fallon Jonathan K JK Tomaras Georgia D GD Alter Galit G Pollard Andrew J AJ
The Journal of experimental medicine 20210201 2
Typhoid Vi vaccines have been shown to be efficacious in children living in endemic regions; however, a widely accepted correlate of protection remains to be established. We applied a systems serology approach to identify Vi-specific serological correlates of protection using samples obtained from participants enrolled in an experimental controlled human infection study. Participants were vaccinated with Vi-tetanus toxoid conjugate (Vi-TT) or unconjugated Vi-polysaccharide (Vi-PS) vaccines and w ...[more]