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The actin regulator profilin 1 is functionally associated with the mammalian centrosome.

ABSTRACT: Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.

SUBMITTER: Nejedla M

PROVIDER: S-EPMC7668531 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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The actin regulator profilin 1 is functionally associated with the mammalian centrosome.

Nejedlá Michaela M Klebanovych Anastasiya A Sulimenko Vadym V Sulimenko Tetyana T Dráberová Eduarda E Dráber Pavel P Karlsson Roger R

Life science alliance 20201112 1

Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the co ...[more]

PMID: 33184056

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