Drivers of within-host genetic diversity in acute infections of viruses.
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ABSTRACT:
SUBMITTER: Gelbart M
PROVIDER: S-EPMC7668575 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Drivers of within-host genetic diversity in acute infections of viruses.
Gelbart Maoz M Harari Sheri S Ben-Ari Ya'ara Y Kustin Talia T Wolf Dana D Mandelboim Michal M Mor Orna O Pennings Pleuni S PS Stern Adi A
PLoS pathogens 20201104 11
Genetic diversity is the fuel of evolution and facilitates adaptation to novel environments. However, our understanding of what drives differences in the genetic diversity during the early stages of viral infection is somewhat limited. Here, we use ultra-deep sequencing to interrogate 43 clinical samples taken from early infections of the human-infecting viruses HIV, RSV and CMV. Hundreds to thousands of virus templates were sequenced per sample, allowing us to reveal dramatic differences in wit ...[more]
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