Albuminuria and Estimated GFR as Risk Factors for Dementia in Midlife and Older Age: Findings From the ARIC Study.

ABSTRACT:

Rationale & objective

Evidence is limited on how estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR) relate to dementia at different ages. We evaluated eGFR and UACR in midlife and older age as risk factors for dementia. Additionally, we assessed whether the association between eGFR and dementia is altered when cystatin C and β₂-microglobulin (B2M) levels are used for GFR estimation.

Study design

Prospective cohort study.

Setting & participants

Two baselines from the Atherosclerosis Risk in Communities (ARIC) Study were used: visit 4 (1996-1998), including 9,967 participants 54 to 74 years old, and visit 5 (2011-2013), including 4,626 participants 70 to 90 years old. Participants were followed up until 2017.

Predictors

SUBMITTER: Scheppach JB 

PROVIDER: S-EPMC7669634 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature