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Stairway Plot 2: demographic history inference with folded SNP frequency spectra.


ABSTRACT: Inferring the demographic histories of populations has wide applications in population, ecological, and conservation genomics. We present Stairway Plot 2, a cross-platform program package for this task using SNP frequency spectra. It is based on a nonparametric method with the capability of handling folded SNP frequency spectra (that is, when the ancestral alleles of the SNPs are unknown) of thousands of samples produced with genotyping-by-sequencing technologies; therefore, it is particularly suitable for nonmodel organisms.

SUBMITTER: Liu X 

PROVIDER: S-EPMC7670622 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Stairway Plot 2: demographic history inference with folded SNP frequency spectra.

Liu Xiaoming X   Fu Yun-Xin YX  

Genome biology 20201117 1


Inferring the demographic histories of populations has wide applications in population, ecological, and conservation genomics. We present Stairway Plot 2, a cross-platform program package for this task using SNP frequency spectra. It is based on a nonparametric method with the capability of handling folded SNP frequency spectra (that is, when the ancestral alleles of the SNPs are unknown) of thousands of samples produced with genotyping-by-sequencing technologies; therefore, it is particularly s  ...[more]

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