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HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region.


ABSTRACT: INTRODUCTION:We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS:Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region. RESULTS:A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype. CONCLUSIONS:This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.

SUBMITTER: Pontes GS 

PROVIDER: S-EPMC7670738 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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<h4>Introduction</h4>We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil.<h4>Methods</h4>Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region.<h4>Results</h4>A 29-year-old male carrier of sickle cell anemia w  ...[more]

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