Ontology highlight
ABSTRACT:
SUBMITTER: Crosse EI
PROVIDER: S-EPMC7671940 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Crosse Edie I EI Gordon-Keylock Sabrina S Rybtsov Stanislav S Binagui-Casas Anahi A Felchle Hannah H Nnadi Nneka C NC Kirschner Kristina K Chandra Tamir T Tamagno Sara S Webb David J DJ Rossi Fiona F Anderson Richard A RA Medvinsky Alexander A
Cell stem cell 20200917 5
Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros (AGM) region. Studies of model organisms defined intersecting signaling pathways that converge to promote HSC emergence predominantly in the ventral domain of the dorsal aorta. Much less is known about mechanisms driving HSC development in humans. Here, to identify secreted signals underlying human HSC development, we combined spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta wit ...[more]