Ontology highlight
ABSTRACT:
SUBMITTER: Comiskey DF
PROVIDER: S-EPMC7672090 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Comiskey Daniel F DF He Huiling H Liyanarachchi Sandya S Sheikh Mehek S MS Hendrickson Isabella V IV Yu Lianbo L Brock Pamela L PL de la Chapelle Albert A
Scientific reports 20201117 1
Papillary thyroid carcinoma (PTC) is the most common histotype of thyroid carcinoma. The heritability of PTC is high compared to other cancers, but its underlying causes are unknown. A recent genome-wide association study revealed the association of a variant at the 5q22 locus, rs73227498, with PTC predisposition. We report that rs17134155, a variant in high linkage disequilibrium with rs73227498, is located in an enhancer region downstream of coding transcripts of EPB41L4A. Rs17134155 showed si ...[more]