Exploring the Link Between Additive Heritability and Prediction Accuracy From a Ridge Regression Perspective.
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ABSTRACT:
SUBMITTER: Frouin A
PROVIDER: S-EPMC7672157 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:PURPOSE:To obviate online slice-by-slice RF shim optimization and reduce B1+ mapping requirements for patient-specific RF shimming in high-field magnetic resonance imaging. THEORY AND METHODS:RF Shim Prediction by Iteratively Projected Ridge Regression (PIPRR) predicts patient-specific, SAR-efficient RF shims with a machine learning approach that merges learning with training shim design. To evaluate it, a set of B1+ maps was simulated for 100 human heads for a 24-element coil at 7T. Features were derived from tissue masks and the DC Fourier coefficients of the coils' B1+ maps in each slice, which were used for kernelized ridge regression prediction of SAR-efficient RF shim weights. Predicted shims were compared to directly designed shims, circularly polarized mode, and nearest-neighbor shims predicted using the same features. RESULTS:PIPRR predictions had 87% and 13% lower B1+ coefficients of variation compared to circularly polarized mode and nearest-neighbor shims, respectively, and achieved homogeneity and SAR similar to that of directly designed shims. Predictions were calculated in 4.92 ms on average. CONCLUSION:PIPRR predicted uniform, SAR-efficient RF shims, and could save a large amount of B1+ mapping and computation time in RF-shimmed ultra-high field magnetic resonance imaging.
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Project description:Ridge regression is a regularization technique that penalizes the L2-norm of the coefficients in linear regression. One of the challenges of using ridge regression is the need to set a hyperparameter (α) that controls the amount of regularization. Cross-validation is typically used to select the best α from a set of candidates. However, efficient and appropriate selection of α can be challenging. This becomes prohibitive when large amounts of data are analyzed. Because the selected α depends on the scale of the data and correlations across predictors, it is also not straightforwardly interpretable. The present work addresses these challenges through a novel approach to ridge regression. We propose to reparameterize ridge regression in terms of the ratio γ between the L2-norms of the regularized and unregularized coefficients. We provide an algorithm that efficiently implements this approach, called fractional ridge regression, as well as open-source software implementations in Python and matlab (https://github.com/nrdg/fracridge). We show that the proposed method is fast and scalable for large-scale data problems. In brain imaging data, we demonstrate that this approach delivers results that are straightforward to interpret and compare across models and datasets. Fractional ridge regression has several benefits: the solutions obtained for different γ are guaranteed to vary, guarding against wasted calculations; and automatically span the relevant range of regularization, avoiding the need for arduous manual exploration. These properties make fractional ridge regression particularly suitable for analysis of large complex datasets.
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