Why do some asthma patients respond poorly to glucocorticoid therapy?
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ABSTRACT:
SUBMITTER: Henderson I
PROVIDER: S-EPMC7672256 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Why do some asthma patients respond poorly to glucocorticoid therapy?
Henderson Ishbel I Caiazzo Elisabetta E McSharry Charles C Guzik Tomasz J TJ Maffia Pasquale P
Pharmacological research 20200908
Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma. They bind intracellular glucocorticoid receptors to trigger increased expression of anti-inflammatory genes and suppression of pro-inflammatory gene activation in asthmatic airways. In the majority of asthma patients, inhaled glucocorticoids are clinically efficacious, improving lung function and preventing exacerbations. However, 5-10 % of the asthmatic population respond poorly to high dose inhaled a ...[more]
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