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In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa.


ABSTRACT: Our hollow-fiber infection model simulated the projected steady-state pharmacokinetics of ceftolozane and tazobactam in lung epithelial lining fluid of patients with pneumonia receiving 3 g of ceftolozane/tazobactam every 8 hours. Results confirmed the previously established in vitro activity of ceftolozane/tazobactam at and above approved breakpoints against multidrug-resistant Pseudomonas aeruginosa, regardless of Pseudomonas-derived cephalosporinase allele.

SUBMITTER: Carr D 

PROVIDER: S-EPMC7672432 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant <i>Pseudomonas Aeruginosa</i>.

Carr Donna D   Zhang Zufei Z   Si Qian Q   Racine Fred F   Xiao Jing Chen JC   Katwaru Ravi R   Wismer Michael K MK   Johnson Matthew G MG   Feng Hwa-Ping HP   Young Katherine K   Rizk Matthew L ML   Motyl Mary M  

Open forum infectious diseases 20201008 11


Our hollow-fiber infection model simulated the projected steady-state pharmacokinetics of ceftolozane and tazobactam in lung epithelial lining fluid of patients with pneumonia receiving 3 g of ceftolozane/tazobactam every 8 hours. Results confirmed the previously established in vitro activity of ceftolozane/tazobactam at and above approved breakpoints against multidrug-resistant <i>Pseudomonas aeruginosa</i>, regardless of <i>Pseudomonas</i>-derived cephalosporinase allele. ...[more]

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