Ontology highlight
ABSTRACT:
SUBMITTER: Carr D
PROVIDER: S-EPMC7672432 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Carr Donna D Zhang Zufei Z Si Qian Q Racine Fred F Xiao Jing Chen JC Katwaru Ravi R Wismer Michael K MK Johnson Matthew G MG Feng Hwa-Ping HP Young Katherine K Rizk Matthew L ML Motyl Mary M
Open forum infectious diseases 20201008 11
Our hollow-fiber infection model simulated the projected steady-state pharmacokinetics of ceftolozane and tazobactam in lung epithelial lining fluid of patients with pneumonia receiving 3 g of ceftolozane/tazobactam every 8 hours. Results confirmed the previously established in vitro activity of ceftolozane/tazobactam at and above approved breakpoints against multidrug-resistant <i>Pseudomonas aeruginosa</i>, regardless of <i>Pseudomonas</i>-derived cephalosporinase allele. ...[more]