Ontology highlight
ABSTRACT:
SUBMITTER: He F
PROVIDER: S-EPMC7672443 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
He Feng F DuPrez Kevin K Hilario Eduardo E Chen Zhenhang Z Fan Li L
Nucleic acids research 20201101 20
Nucleotide excision repair (NER) removes various DNA lesions caused by UV light and chemical carcinogens. The DNA helicase XPB plays a key role in DNA opening and coordinating damage incision by nucleases during NER, but the underlying mechanisms remain unclear. Here, we report crystal structures of XPB from Sulfurisphaera tokodaii (St) bound to the nuclease Bax1 and their complex with a bubble DNA having one arm unwound in the crystal. StXPB and Bax1 together spirally encircle 10 base pairs of ...[more]